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Safety |
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| There are currently no reported safety issues
or contraindications with NKCP NattoTabs .
Being an extract from a traditional food, this product
is very safe to take. We do advise, however, that if you have
a specific medical problem or if you are taking
prescription medications (especially medication relating to thrombosis
or blood circulation), you consult your doctor before
taking
NKCP NattoTabs . Over 14 safety studies have been
carried out with NKCP NattoTabs , all of which
show absolutely no safety problems or toxicity. Eight of these
studies are summarized below: |
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| 1. |
Mutagenicity |
Negative |
| 2. |
Acute toxicity (rat) |
LD50 > 5,000 mg/kg |
| 3. |
Subacute toxicity (rat) |
Non-toxic-effect dose > 1,325 mg/kg body
weight/day male
Non-toxic-effect dose > 1,541 mg/kg body weight/day female
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| 4. |
Antigenicity (guinea pig) |
None (subcutaneous, intravenous) |
| 5. |
Excess intake (rat) |
Rat models of prolonged coagulation given five times the
normal dose through the duodenum showed no bleeding, and
NKCP induced no remarkable symptoms in the coagulation system. |
| 6. |
Prolongation of bleeding time (rat) |
An oral dose of a maximum 300 mg/kg body weight had no
effect on the prolongation of the bleeding time. |
| 7. |
Long-term intake in humans: |
Eight healthy adults were given 750 mg of NKCP daily for
6 weeks and no clinical adverse effects were observed. |
| 8. |
Excess intake in humans |
23 healthy adults were given 1,250 mg of NKCP daily for
7 days and no clinical adverse effects were observed. |
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